Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance

The oncoprotein transcription factor MYC is overexpressed in the majority of cancers. Key to its oncogenic activity is the ability of MYC to regulate gene expression patterns that drive and maintain the malignant state. MYC is also considered a validated anticancer target, but efforts to pharmacolog...

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Detalles Bibliográficos
Autores principales: Thomas, Lance R., Adams, Clare M., Wang, Jing, Weissmiller, April M., Creighton, Joy, Lorey, Shelly L., Liu, Qi, Fesik, Stephen W., Eischen, Christine M., Tansey, William P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911241/
https://www.ncbi.nlm.nih.gov/pubmed/31767764
http://dx.doi.org/10.1073/pnas.1910391116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911241/
https://www.ncbi.nlm.nih.gov/pubmed/31767764
http://dx.doi.org/10.1073/pnas.1910391116

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