Cargando…

Blocking AMPK/ULK1-dependent autophagy promoted apoptosis and suppressed colon cancer growth

BACKGROUND: Autophagy is an evolutionarily conserved process through which cells degrade and recycle cytoplasm. The relation among autophagy, apoptosis and tumor is highly controversial until now and the molecular mechanism is poorly understood. METHODS: Cell viability and apoptosis were detected by...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Jing, Long, Shuaiyu, Wang, Huanan, Liu, Nannan, Zhang, Chuchu, Zhang, Lingling, Zhang, Yingjie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911288/ https://www.ncbi.nlm.nih.gov/pubmed/31871431 http://dx.doi.org/10.1186/s12935-019-1054-0

Ejemplares similares

The Association of AMPK with ULK1 Regulates Autophagy
por: Lee, Jong Woo, et al.
Publicado: (2010)

Targeting Akt by SC66 triggers GSK-3β mediated apoptosis in colon cancer therapy
por: Liu, Yeying, et al.
Publicado: (2019)

AMPK/mTOR/ULK1 Axis-Mediated Pathway Participates in Apoptosis and Autophagy Induction by Oridonin in Colon Cancer DLD-1 Cells
por: Bu, Heqi, et al.
Publicado: (2020)

STAT3 suppresses the AMPKα/ULK1‐dependent induction of autophagy in glioblastoma cells
por: Bhattacharya, Sujoy, et al.
Publicado: (2022)

Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Osteogenic Differentiation by Modulating AMPK/ULK1‐Dependent Autophagy
por: Li, Zheng, et al.
Publicado: (2019)

Aurora-B knockdown inhibits osteosarcoma metastasis by inducing autophagy via the mTOR/ULK1 pathway
por: Wu, Xin, et al.
Publicado: (2020)

Osthole Suppresses Knee Osteoarthritis Development by Enhancing Autophagy Activated via the AMPK/ULK1 Pathway
por: Ma, Teng, et al.
Publicado: (2022)

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs
por: Dite, Toby A., et al.
Publicado: (2017)

Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth
por: Wang, Huanan, et al.
Publicado: (2016)

Nicotinamide N-methyltransferase inhibits autophagy induced by oxidative stress through suppressing the AMPK pathway in breast cancer cells
por: Yu, Haitao, et al.
Publicado: (2020)

Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice
por: Zhang, Pan, et al.
Publicado: (2017)

Silencing of SNHG6 induced cell autophagy by targeting miR-26a-5p/ULK1 signaling pathway in human osteosarcoma
por: Zhu, Xin, et al.
Publicado: (2019)

LncRNA SNHG6 promotes chemoresistance through ULK1-induced autophagy by sponging miR-26a-5p in colorectal cancer cells
por: Wang, Xinke, et al.
Publicado: (2019)

Berberine induces autophagy in glioblastoma by targeting the AMPK/mTOR/ULK1-pathway
por: Wang, Jiwei, et al.
Publicado: (2016)

Retraction Note: Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice
por: Zhang, Pan, et al.
Publicado: (2022)

Prodigiosin inhibits cholangiocarcinoma cell proliferation and induces apoptosis via suppressing SNAREs-dependent autophagy
por: Zheng, Dijie, et al.
Publicado: (2021)

Silencing of EEF2K (eukaryotic elongation factor-2 kinase) reveals AMPK-ULK1-dependent autophagy in colon cancer cells
por: Xie, Chuan-Ming, et al.
Publicado: (2014)

PEDF inhibits non-small cell lung cancer proliferation by suppressing autophagy through downregulation of AMPK-ULK1 signaling
por: Miao, Haoran, et al.
Publicado: (2022)

Activation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection
por: Fan, Xue-Yu, et al.
Publicado: (2015)

SIRT6 promotes autophagy through direct interaction with ULK1 and competitive binding to PUMA
por: Wu, Zhongguang, et al.
Publicado: (2022)

Metformin exerts anti-AR-negative prostate cancer activity via AMPK/autophagy signaling pathway
por: Chen, Chunyang, et al.
Publicado: (2021)

RAC3 influences the chemoresistance of colon cancer cells through autophagy and apoptosis inhibition
por: Rubio, María Fernanda, et al.
Publicado: (2017)

Relieving lipid accumulation through UCP1 suppresses the progression of acute kidney injury by promoting the AMPK/ULK1/autophagy pathway
por: Xiong, Wei, et al.
Publicado: (2021)

Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling
por: Lin, Chenchu, et al.
Publicado: (2021)

Co-targeting hexokinase 2-mediated Warburg effect and ULK1-dependent autophagy suppresses tumor growth of PTEN- and TP53-deficiency-driven castration-resistant prostate cancer
por: Wang, Lei, et al.
Publicado: (2016)

Lipopolysaccharide-Induced Dephosphorylation of AMPK-Activated Protein Kinase Potentiates Inflammatory Injury via Repression of ULK1-Dependent Autophagy
por: Fan, Kerui, et al.
Publicado: (2018)

AMPK/Ulk1-dependent autophagy as a key mTOR regulator in the context of cell pluripotency
por: Suvorova, Irina I., et al.
Publicado: (2019)

Marsdenia tenacissima extract induces apoptosis and suppresses autophagy through ERK activation in lung cancer cells
por: Jiao, Yan-Na, et al.
Publicado: (2018)

Betulinic acid induces autophagy-dependent apoptosis via Bmi-1/ROS/AMPK-mTOR-ULK1 axis in human bladder cancer cells
por: Zhang, Yan, et al.
Publicado: (2021)

Trifolirhizin induces autophagy-dependent apoptosis in colon cancer via AMPK/mTOR signaling
por: Sun, Dongdong, et al.
Publicado: (2020)

RAMS11 promotes CRC through mTOR-dependent inhibition of autophagy, suppression of apoptosis, and promotion of epithelial-mesenchymal transition
por: Islam Khan, Md Zahirul, et al.
Publicado: (2021)

Puerarin protects rat brain against ischemia/reperfusion injury by suppressing autophagy via the AMPK-mTOR-ULK1 signaling pathway
por: Wang, Jin-Feng, et al.
Publicado: (2018)

Salvia chinensia Benth induces autophagy in esophageal cancer cells via AMPK/ULK1 signaling pathway
por: Jia, Lei, et al.
Publicado: (2022)

Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: tumor suppressive role of klotho in gastric cancer
por: Xie, Biao, et al.
Publicado: (2013)

CARM1 promotes gastric cancer progression by regulating TFE3 mediated autophagy enhancement through the cytoplasmic AMPK-mTOR and nuclear AMPK-CARM1-TFE3 signaling pathways
por: Yang, Suzhen, et al.
Publicado: (2022)

AXL Promotes Metformin-Induced Apoptosis Through Mediation of Autophagy by Activating ROS-AMPK-ULK1 Signaling in Human Esophageal Adenocarcinoma
por: Hong, Jun, et al.
Publicado: (2022)

Blockage of AMPK-ULK1 pathway mediated autophagy promotes cell apoptosis to increase doxorubicin sensitivity in breast cancer (BC) cells: an in vitro study
por: Yu, Libo, et al.
Publicado: (2021)

Icariin improves brain function decline in aging rats by enhancing neuronal autophagy through the AMPK/mTOR/ULK1 pathway
por: Zheng, Jie, et al.
Publicado: (2021)

Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy
por: Lu, Qing-Bo, et al.
Publicado: (2022)

Ebastine exerts antitumor activity and induces autophagy by activating AMPK/ULK1 signaling in an IPMK-dependent manner in osteosarcoma
por: Pan, Zhen, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_qtnhgqbmrge2hn598eq0fmp6pc