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TIMP-2 secreted by monocyte-like cells is a potent suppressor of invadopodia formation in pancreatic cancer cells

BACKGROUND: Monocytes are a major component of the tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC). However, the complex interactions between tumor cells and monocytes and their role in tumor invasion have not been fully established. METHODS: To specifically test the impact o...

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Detalles Bibliográficos
Autores principales: Benzing, Christian, Lam, Hoyin, Tsang, Chi Man, Rimmer, Alexander, Arroyo-Berdugo, Yoana, Calle, Yolanda, Wells, Claire M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911299/
https://www.ncbi.nlm.nih.gov/pubmed/31836008
http://dx.doi.org/10.1186/s12885-019-6429-z