Small Cell Lung Cancer Derived from Adenocarcinoma with Mutant Epidermal Growth Factor Receptor Provides a Signature of Transcriptional Alteration in Tumor Cells

Small cell lung cancer (SCLC) transformation of epidermal growth factor receptor (EGFR) mutant adenocarcinoma (ADC) during EGFR tyrosine kinase inhibitor (TKI) treatment is an example of a rare subset of acquired drug resistance. We herein report the case of a 75-year-old man treated with afatinib w...

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Autores principales: Tenjin, Yuki, Nakamura, Kazuyoshi, Ishizuka, Shiho, Saruwatari, Koichi, Sato, Ryo, Tomita, Yusuke, Saeki, Sho, Ichiyasu, Hidenori, Fujii, Kazuhiko, Ito, Takaaki, Sakagami, Takuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911746/
https://www.ncbi.nlm.nih.gov/pubmed/31292388
http://dx.doi.org/10.2169/internalmedicine.2988-19
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author Tenjin, Yuki
Nakamura, Kazuyoshi
Ishizuka, Shiho
Saruwatari, Koichi
Sato, Ryo
Tomita, Yusuke
Saeki, Sho
Ichiyasu, Hidenori
Fujii, Kazuhiko
Ito, Takaaki
Sakagami, Takuro
author_facet Tenjin, Yuki
Nakamura, Kazuyoshi
Ishizuka, Shiho
Saruwatari, Koichi
Sato, Ryo
Tomita, Yusuke
Saeki, Sho
Ichiyasu, Hidenori
Fujii, Kazuhiko
Ito, Takaaki
Sakagami, Takuro
author_sort Tenjin, Yuki
collection PubMed
description Small cell lung cancer (SCLC) transformation of epidermal growth factor receptor (EGFR) mutant adenocarcinoma (ADC) during EGFR tyrosine kinase inhibitor (TKI) treatment is an example of a rare subset of acquired drug resistance. We herein report the case of a 75-year-old man treated with afatinib who was then diagnosed with SCLC transformation. After two years of successful treatment with afatinib, the tumor relapsed, and a re-biopsy revealed SCLC harboring EGFR exon 19 deletion. We encountered a case of transcriptional alteration, potentially important for SCLC transformation of EGFR mutant lung ADC, that was recognized via the expression of NOTCH, ASCL1 and RB1 on immunohistochemical staining.
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spelling pubmed-69117462019-12-16 Small Cell Lung Cancer Derived from Adenocarcinoma with Mutant Epidermal Growth Factor Receptor Provides a Signature of Transcriptional Alteration in Tumor Cells Tenjin, Yuki Nakamura, Kazuyoshi Ishizuka, Shiho Saruwatari, Koichi Sato, Ryo Tomita, Yusuke Saeki, Sho Ichiyasu, Hidenori Fujii, Kazuhiko Ito, Takaaki Sakagami, Takuro Intern Med Case Report Small cell lung cancer (SCLC) transformation of epidermal growth factor receptor (EGFR) mutant adenocarcinoma (ADC) during EGFR tyrosine kinase inhibitor (TKI) treatment is an example of a rare subset of acquired drug resistance. We herein report the case of a 75-year-old man treated with afatinib who was then diagnosed with SCLC transformation. After two years of successful treatment with afatinib, the tumor relapsed, and a re-biopsy revealed SCLC harboring EGFR exon 19 deletion. We encountered a case of transcriptional alteration, potentially important for SCLC transformation of EGFR mutant lung ADC, that was recognized via the expression of NOTCH, ASCL1 and RB1 on immunohistochemical staining. The Japanese Society of Internal Medicine 2019-07-10 2019-11-15 /pmc/articles/PMC6911746/ /pubmed/31292388 http://dx.doi.org/10.2169/internalmedicine.2988-19 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Tenjin, Yuki
Nakamura, Kazuyoshi
Ishizuka, Shiho
Saruwatari, Koichi
Sato, Ryo
Tomita, Yusuke
Saeki, Sho
Ichiyasu, Hidenori
Fujii, Kazuhiko
Ito, Takaaki
Sakagami, Takuro
Small Cell Lung Cancer Derived from Adenocarcinoma with Mutant Epidermal Growth Factor Receptor Provides a Signature of Transcriptional Alteration in Tumor Cells
title Small Cell Lung Cancer Derived from Adenocarcinoma with Mutant Epidermal Growth Factor Receptor Provides a Signature of Transcriptional Alteration in Tumor Cells
title_full Small Cell Lung Cancer Derived from Adenocarcinoma with Mutant Epidermal Growth Factor Receptor Provides a Signature of Transcriptional Alteration in Tumor Cells
title_fullStr Small Cell Lung Cancer Derived from Adenocarcinoma with Mutant Epidermal Growth Factor Receptor Provides a Signature of Transcriptional Alteration in Tumor Cells
title_full_unstemmed Small Cell Lung Cancer Derived from Adenocarcinoma with Mutant Epidermal Growth Factor Receptor Provides a Signature of Transcriptional Alteration in Tumor Cells
title_short Small Cell Lung Cancer Derived from Adenocarcinoma with Mutant Epidermal Growth Factor Receptor Provides a Signature of Transcriptional Alteration in Tumor Cells
title_sort small cell lung cancer derived from adenocarcinoma with mutant epidermal growth factor receptor provides a signature of transcriptional alteration in tumor cells
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911746/
https://www.ncbi.nlm.nih.gov/pubmed/31292388
http://dx.doi.org/10.2169/internalmedicine.2988-19
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