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The Effect of Glutamatergic Modulators on Extracellular Glutamate: How Does this Information Contribute to the Discovery of Novel Antidepressants?

BACKGROUND: In the search for new antidepressants, clinical researchers have been using drugs that simultaneously modulate multiple targets. During preclinical and clinical trials, the glutamatergic modulators riluzole and ketamine have received particular attention. Glutamatergic agents have a modu...

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Detalles Bibliográficos
Autor principal: Frizzo, Marcos Emilio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911922/
https://www.ncbi.nlm.nih.gov/pubmed/31871505
http://dx.doi.org/10.1016/j.curtheres.2019.100566