Cargando…

20(R)-Ginsenoside Rg3 Influences Cancer Stem Cell Properties and the Epithelial-Mesenchymal Transition in Colorectal Cancer via the SNAIL Signaling Axis

BACKGROUND: Cancer stem cells (CSCs) have been proposed as central drivers of cancer relapse in many cancers. In the present study, we investigated the inhibitory effect of 20(R)-Ginsenoside Rg3 (Rg3R), a major active component of ginseng saponin, on CSC-like cells and the Epithelial-Mesenchymal Tra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Phi, Lan Thi Hanh, Wijaya, Yoseph Toni, Sari, Ita Novita, Kim, Kwang Seock, Yang, Ying-Gui, Lee, Min-Woo, Kwon, Hyog Young
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912006/ https://www.ncbi.nlm.nih.gov/pubmed/31849492 http://dx.doi.org/10.2147/OTT.S219063

Ejemplares similares

The anti‐metastatic effect of ginsenoside Rb2 in colorectal cancer in an EGFR/SOX2‐dependent manner
por: Phi, Lan Thi Hanh, et al.
Publicado: (2018)

Hedgehog Signaling in Cancer: A Prospective Therapeutic Target for Eradicating Cancer Stem Cells
por: Sari, Ita Novita, et al.
Publicado: (2018)

Interferon‐induced transmembrane protein 1‐mediated EGFR/SOX2 signaling axis is essential for progression of non‐small cell lung cancer
por: Yang, Ying‐Gui, et al.
Publicado: (2018)

miR551b Regulates Colorectal Cancer Progression by Targeting the ZEB1 Signaling Axis
por: Kim, Kwang Seock, et al.
Publicado: (2019)

Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment
por: Phi, Lan Thi Hanh, et al.
Publicado: (2018)

Amelioration of muscle wasting by gintonin in cancer cachexia
por: Wijaya, Yoseph Toni, et al.
Publicado: (2021)

Interferon-induced transmembrane protein 1 (IFITM1) is required for the progression of colorectal cancer
por: Sari, Novita Ita, et al.
Publicado: (2016)

Ginsenoside Rd ameliorates muscle wasting by suppressing the signal transducer and activator of transcription 3 pathway
por: Wijaya, Yoseph Toni, et al.
Publicado: (2022)

Cancer cachexia: molecular mechanisms and treatment strategies
por: Setiawan, Tania, et al.
Publicado: (2023)

Toll-Like Receptor 2-Mediated Suppression of Colorectal Cancer Pathogenesis by Polysaccharide A From Bacteroides fragilis
por: Sittipo, Panida, et al.
Publicado: (2018)

Ginsenoside Rg1 and 20(S)-Rg3 Induce IgA Production by Mouse B Cells
por: Park, Ha-Yan, et al.
Publicado: (2015)

20(S)-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway
por: Zhang, Fei, et al.
Publicado: (2015)

Evaluation of the gastroprotective effects of 20 (S)-ginsenoside Rg3 on gastric ulcer models in mice
por: Zhang, Kai, et al.
Publicado: (2019)

20(S)-Ginsenoside Rg3 Promotes HeLa Cell Apoptosis by Regulating Autophagy
por: Bian, Shuai, et al.
Publicado: (2019)

Inhibition of Herpes Simplex Viruses, Types 1 and 2, by Ginsenoside 20(S)-Rg3
por: Wright, Stephen M., et al.
Publicado: (2020)

Effects of ginsenoside Rg3 on epigenetic modification in ovarian cancer cells
por: Zhao, Lingqin, et al.
Publicado: (2019)

Anti-Angiogenic Properties of Ginsenoside Rg3
por: Nakhjavani, Maryam, et al.
Publicado: (2020)

Pharmacological activities of ginsenoside Rg5 (Review)
por: Liu, Ming-Yang, et al.
Publicado: (2021)

Comparative Pharmacokinetics of Ginsenoside Rg(3) and Ginsenoside Rh(2) after Oral Administration of Ginsenoside Rg(3) in Normal and Walker 256 Tumor-bearing Rats
por: Fan, He, et al.
Publicado: (2016)

20(S)-Ginsenoside Rg3 Promotes Senescence And Apoptosis In Gallbladder Cancer Cells Via The P53 Pathway [Corrigendum]
Publicado: (2019)

Co-treatment with Ginsenoside 20(S)-Rg3 and Curcumin increases Radiosensitivity of MDA-MB-231 Cancer Cell Line
por: Changizi, Vahid, et al.
Publicado: (2021)

20(S)-Ginsenoside Rg(3) is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin
por: Kim, Dong-Gun, et al.
Publicado: (2014)

In Vivo Early Intervention and the Therapeutic Effects of 20(S)-Ginsenoside Rg3 on Hypertrophic Scar Formation
por: Cheng, Liying, et al.
Publicado: (2014)

Role of microRNA-520h in 20(R)-ginsenoside-Rg3-mediated angiosuppression
por: Keung, Man-Hong, et al.
Publicado: (2016)

Molecular signaling of ginsenosides Rb1, Rg1, and Rg3 and their mode of actions
por: Mohanan, Padmanaban, et al.
Publicado: (2018)

Relationship Between Ginsenoside Rg3 and Metabolic Syndrome
por: Lee, Hyunji, et al.
Publicado: (2020)

Protective effect and mechanism of ginsenoside Rg2 on atherosclerosis
por: Xue, Qianqian, et al.
Publicado: (2023)

Treatment with 20(S)-ginsenoside Rg3 reverses multidrug resistance in A549/DDP xenograft tumors
por: Liu, Chao, et al.
Publicado: (2018)

20(S)‐ginsenoside‐Rg3 reverses temozolomide resistance and restrains epithelial‐mesenchymal transition progression in glioblastoma
por: Chen, Zheng, et al.
Publicado: (2018)

Metabolism of 20(S)-Ginsenoside Rg(2) by Rat Liver Microsomes: Bioactivation to SIRT1-Activating Metabolites
por: Ma, Li-Yuan, et al.
Publicado: (2016)

Evaluation of 20(S)-ginsenoside Rg3 loaded hydrogel for the treatment of perianal ulcer in a rat model
por: Jin, Longhai, et al.
Publicado: (2022)

Pharmacokinetic Comparison of 20(R)- and 20(S)-Ginsenoside Rh1 and 20(R)- and 20(S)-Ginsenoside Rg3 in Rat Plasma following Oral Administration of Radix Ginseng Rubra and Sheng-Mai-San Extracts
por: Fan, Xiaomei, et al.
Publicado: (2017)

Ginsenoside 20(S)-Rg3 Targets HIF-1α to Block Hypoxia-Induced Epithelial-Mesenchymal Transition in Ovarian Cancer Cells
por: Liu, Ting, et al.
Publicado: (2014)

Ginsenoside-Rg5 induces apoptosis and DNA damage in human cervical cancer cells
por: LIANG, LI-DAN, et al.
Publicado: (2015)

Phosphoproteomic analysis of the antitumor effects of ginsenoside Rg3 in human breast cancer cells
por: Zou, Mingjin, et al.
Publicado: (2018)

Ginsenoside Rg3: Potential Molecular Targets and Therapeutic Indication in Metastatic Breast Cancer
por: Nakhjavani, Maryam, et al.
Publicado: (2019)

Ginsenoside Rg1 suppresses cancer cell proliferation through perturbing mitotic progression
por: Hong, Jihee, et al.
Publicado: (2022)

Kinetic study for the optimization of ginsenoside Rg3 production by heat treatment of ginsenoside Rb1
por: Vo, Hoang Tung, et al.
Publicado: (2015)

Effects of Ginsenosides Rg1 on Osteoblasts Cultured with Ti Particles
por: Lin, Yu, et al.
Publicado: (2012)

Protective effect of ginsenoside Rg1 on lidocaine-induced apoptosis
por: LI, HUI, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_cpbmcuacmmsn13rcbtebhm4eij