Off-Target Deletion of Conditional Dbc1 Allele in the Foxp3(YFP-Cre) Mouse Line under Specific Setting

The Cre-LoxP conditional knockout strategy has been used extensively to study gene function in a specific cell-type. In this study, the authors tried to engineer mice in which the Dbc1 gene is conditionally knocked out in Treg cells. Unexpectedly, the conditional Dbc1 allele was completely deleted w...

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Detalles Bibliográficos
Autores principales: Xie, Chichu, Zhu, Fangming, Wang, Julie, Zhang, Weizhou, Bellanti, Joseph A., Li, Bin, Brand, David, Olsen, Nancy, Zheng, Song Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912351/
https://www.ncbi.nlm.nih.gov/pubmed/31652947
http://dx.doi.org/10.3390/cells8111309

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912351/
https://www.ncbi.nlm.nih.gov/pubmed/31652947
http://dx.doi.org/10.3390/cells8111309

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