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Off-Target Deletion of Conditional Dbc1 Allele in the Foxp3(YFP-Cre) Mouse Line under Specific Setting
The Cre-LoxP conditional knockout strategy has been used extensively to study gene function in a specific cell-type. In this study, the authors tried to engineer mice in which the Dbc1 gene is conditionally knocked out in Treg cells. Unexpectedly, the conditional Dbc1 allele was completely deleted w...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912351/ https://www.ncbi.nlm.nih.gov/pubmed/31652947 http://dx.doi.org/10.3390/cells8111309 |