Direct RNA sequencing enables m(6)A detection in endogenous transcript isoforms at base-specific resolution

Direct RNA sequencing holds great promise for the de novo identification of RNA modifications at single-coordinate resolution; however, interpretation of raw sequencing output to discover modified bases remains a challenge. Using Oxford Nanopore's direct RNA sequencing technology, we developed...

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Detalles Bibliográficos
Autores principales: Lorenz, Daniel A., Sathe, Shashank, Einstein, Jaclyn M., Yeo, Gene W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Bioinformatics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913132/
https://www.ncbi.nlm.nih.gov/pubmed/31624092
http://dx.doi.org/10.1261/rna.072785.119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913132/
https://www.ncbi.nlm.nih.gov/pubmed/31624092
http://dx.doi.org/10.1261/rna.072785.119

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