Reprofiling of pyrimidine-based DAPK1/CSF1R dual inhibitors: identification of 2,5-diamino-4-pyrimidinol derivatives as novel potential anticancer lead compounds

Hybridization of reported weakly active antiproliferative hit 5-amino-4-pyrimidinol derivative with 2-anilino-4-phenoxypyrimidines suggests a series of 2,5-diamino-4-pyrimidinol derivatives as potential antiproliferative agents. Few compounds belonging to the proposed series were reported as CSF1R/D...

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Detalles Bibliográficos
Autores principales: Farag, Ahmed K., Hassan, Ahmed H. E., Ahn, Byung Sun, Park, Ki Duk, Roh, Eun Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913669/
https://www.ncbi.nlm.nih.gov/pubmed/31809612
http://dx.doi.org/10.1080/14756366.2019.1699554

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913669/
https://www.ncbi.nlm.nih.gov/pubmed/31809612
http://dx.doi.org/10.1080/14756366.2019.1699554

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