Cargando…

Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy

Appropriate regulation of autophagy is crucial for clearing toxic proteins from cells. Defective autophagy results in accumulation of toxic protein aggregates that detrimentally affect cellular function and organismal survival. Here, we report that the microRNA miR-1 regulates the autophagy pathway...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nehammer, Camilla, Ejlerskov, Patrick, Gopal, Sandeep, Handley, Ava, Ng, Leelee, Moreira, Pedro, Lee, Huikyong, Issazadeh-Navikas, Shohreh, Rubinsztein, David C, Pocock, Roger
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914338/ https://www.ncbi.nlm.nih.gov/pubmed/31799933 http://dx.doi.org/10.7554/eLife.49930

Ejemplares similares

IFNB1/interferon-β-induced autophagy in MCF-7 breast cancer cells counteracts its proapoptotic function
por: Ambjørn, Malene, et al.
Publicado: (2013)

Corrigendum: Neuronal IFN-beta–induced PI3K/Akt-FoxA1 signalling is essential for generation of FoxA1(+)T(reg) cells
por: Liu, Yawei, et al.
Publicado: (2017)

Neuronal IFN-beta–induced PI3K/Akt-FoxA1 signalling is essential for generation of FoxA1(+)T(reg) cells
por: Liu, Yawei, et al.
Publicado: (2017)

DNMT1 regulates expression of MHC class I in post-mitotic neurons
por: Gustafsson, Julie Ry, et al.
Publicado: (2018)

Alerting the immune system via stromal cells is central to the prevention of tumor growth
por: Issazadeh-Navikas, Shohreh
Publicado: (2013)

Genomic innovation of ATD alleviates mistranslation associated with multicellularity in Animalia
por: Kuncha, Santosh Kumar, et al.
Publicado: (2020)

Local therapy with CpG motifs in a murine model of allergic airway inflammation in IFN-β knock-out mice
por: Matheu, Victor, et al.
Publicado: (2005)

Lipid accumulation controls the balance between surface connection and scission of caveolae
por: Hubert, Madlen, et al.
Publicado: (2020)

Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria
por: Qian, Minxian, et al.
Publicado: (2018)

CAV1 alleviated CaOx stones formation via suppressing autophagy-dependent ferroptosis
por: Yang, Yuanyuan, et al.
Publicado: (2022)

β-hydroxybutyrate accumulates in the rat heart during low-flow ischaemia with implications for functional recovery
por: Lindsay, Ross T, et al.
Publicado: (2021)

Targeting mir128-3p alleviates myocardial insulin resistance and prevents ischemia-induced heart failure
por: Ruiz-Velasco, Andrea, et al.
Publicado: (2020)

Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair
por: Hodel, Karl P, et al.
Publicado: (2018)

Genetically incorporated crosslinkers reveal NleE attenuates host autophagy dependent on PSMD10
por: Li, Jingxiang, et al.
Publicado: (2021)

Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy
por: Eapen, Vinay V, et al.
Publicado: (2021)

Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1
por: Zhao, Xiaocheng, et al.
Publicado: (2019)

Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice
por: Ito, Jumpei, et al.
Publicado: (2021)

Correction: Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1
por: Zhao, Xiaocheng, et al.
Publicado: (2020)

The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment
por: Shi, Xiaoshan, et al.
Publicado: (2020)

A somatic proteoglycan controls Notch-directed germ cell fate
por: Gopal, Sandeep, et al.
Publicado: (2021)

Neuronal Responses to Physiological Stress
por: Kagias, Konstantinos, et al.
Publicado: (2012)

Covalent inhibition of endoplasmic reticulum chaperone GRP78 disconnects the transduction of ER stress signals to inflammation and lipid accumulation in diet-induced obese mice
por: Luo, Dan, et al.
Publicado: (2022)

Identification of unique and shared mitochondrial DNA mutations in neurodegeneration and cancer by single-cell mitochondrial DNA structural variation sequencing (MitoSV-seq)
por: Jaberi, Elham, et al.
Publicado: (2020)

Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson’s Disease-like Dementia
por: Ejlerskov, Patrick, et al.
Publicado: (2015)

TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition
por: Ramachandran, Anassuya, et al.
Publicado: (2018)

miR-200a-3p overexpression alleviates diabetic cardiomyopathy injury in mice by regulating autophagy through the FOXO3/Mst1/Sirt3/AMPK axis
por: You, Penghua, et al.
Publicado: (2023)

RhoA Drives T-Cell Activation and Encephalitogenic Potential in an Animal Model of Multiple Sclerosis
por: Manresa-Arraut, Alba, et al.
Publicado: (2018)

Induction of endogenous Type I interferon within the central nervous system plays a protective role in experimental autoimmune encephalomyelitis
por: Khorooshi, Reza, et al.
Publicado: (2015)

Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells
por: Vilaplana-Lopera, Nuria, et al.
Publicado: (2022)

Bibliometric analysis of research on the trends in autophagy
por: Hong, Ting, et al.
Publicado: (2019)

Microorganism-regulated autophagy in gastrointestinal cancer
por: Xu, Jun-Yu, et al.
Publicado: (2023)

Identification of AaAtg8 as a marker of autophagy and a functional autophagy-related protein in Aedes albopictus
por: Qiao, Jialu, et al.
Publicado: (2018)

Specific microRNAs Regulate Heat Stress Responses in Caenorhabditis elegans
por: Nehammer, Camilla, et al.
Publicado: (2015)

Author Correction: Specific microRNAs Regulate Heat Stress Responses in Caenorhabditis elegans
por: Nehammer, Camilla, et al.
Publicado: (2019)

ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation
por: Liu, Yawei, et al.
Publicado: (2020)

Collagen overlays can inhibit leptin and adiponectin secretion but not lipid accumulation in adipocytes
por: Christian, Sherri L., et al.
Publicado: (2018)

Cellular accumulation and cytotoxic effects of zinc oxide nanoparticles in microalga Haematococcus pluvialis
por: Djearamane, Sinouvassane, et al.
Publicado: (2019)

Age- and diet-associated metabolome remodeling characterizes the aging process driven by damage accumulation
por: Avanesov, Andrei S, et al.
Publicado: (2014)

N-acetylcysteine alleviates PCB52-induced hepatotoxicity by repressing oxidative stress and inflammatory responses
por: Zhou, Wen-Tao, et al.
Publicado: (2020)

Mechanism of cargo-directed Atg8 conjugation during selective autophagy
por: Fracchiolla, Dorotea, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_lf83mvstj1o6s5c7ii4phba1cg