Metabolic control of BRISC-SHMT2 assembly regulates immune signaling

SHMT2 regulates one-carbon transfer reactions essential for amino acid and nucleotide metabolism, using PLP as a cofactor. Apo SHMT2 exists as a dimer with unknown functions, whereas PLP binding stabilizes the active, tetrameric state. SHMT2 also promotes inflammatory cytokine signaling by interacti...

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Detalles Bibliográficos
Autores principales: Walden, Miriam, Tian, Lei, Ross, Rebecca, Sykora, Upasana M., Byrne, Dominic P., Hesketh, Emma L., Masandi, Safi K., Cassel, Joel, George, Rachel, Ault, James R., El Oualid, Farid, Pawłowski, Krzysztof, Salvino, Joseph M., Eyers, Patrick A., Ranson, Neil A., Del Galdo, Francesco, Greenberg, Roger A., Zeqiraj, Elton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914362/
https://www.ncbi.nlm.nih.gov/pubmed/31142841
http://dx.doi.org/10.1038/s41586-019-1232-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914362/
https://www.ncbi.nlm.nih.gov/pubmed/31142841
http://dx.doi.org/10.1038/s41586-019-1232-1

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