Cargando…

Metabolic control of BRISC-SHMT2 assembly regulates immune signaling

SHMT2 regulates one-carbon transfer reactions essential for amino acid and nucleotide metabolism, using PLP as a cofactor. Apo SHMT2 exists as a dimer with unknown functions, whereas PLP binding stabilizes the active, tetrameric state. SHMT2 also promotes inflammatory cytokine signaling by interacti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Walden, Miriam, Tian, Lei, Ross, Rebecca, Sykora, Upasana M., Byrne, Dominic P., Hesketh, Emma L., Masandi, Safi K., Cassel, Joel, George, Rachel, Ault, James R., El Oualid, Farid, Pawłowski, Krzysztof, Salvino, Joseph M., Eyers, Patrick A., Ranson, Neil A., Del Galdo, Francesco, Greenberg, Roger A., Zeqiraj, Elton
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914362/ https://www.ncbi.nlm.nih.gov/pubmed/31142841 http://dx.doi.org/10.1038/s41586-019-1232-1

Ejemplares similares

SHMT2 and the BRCC36/BRISC deubiquitinase regulate HIV-1 Tat K63-ubiquitylation and destruction by autophagy
por: Xu, Muyu, et al.
Publicado: (2018)

Spindle assembly at a BRISC pace
por: Short, Ben
Publicado: (2015)

BRISC—An Open Source Pulmonary Nodule Image Retrieval Framework
por: Lam, Michael O., et al.
Publicado: (2007)

SHMT1 and SHMT2 Are Functionally Redundant in Nuclear De novo Thymidylate Biosynthesis
por: Anderson, Donald D., et al.
Publicado: (2009)

BRCA1-A and BRISC: Multifunctional Molecular Machines for Ubiquitin Signaling
por: Rabl, Julius
Publicado: (2020)

The Benefits and Risks of Iron interventionS in Children (BRISC) trial: Statistical analysis plan
por: Braat, Sabine, et al.
Publicado: (2020)

The deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cells
por: Yan, Kaowen, et al.
Publicado: (2015)

Cancer proteome and metabolite changes linked to SHMT2
por: Tong, Jiefei, et al.
Publicado: (2020)

The deubiquitinating enzyme complex BRISC regulates Aurora B activation via lysine-63-linked ubiquitination in mitosis
por: Li, Qin, et al.
Publicado: (2022)

SHMT2 Overexpression Predicts Poor Prognosis in Intrahepatic Cholangiocarcinoma
por: Ning, Shanglei, et al.
Publicado: (2018)

SHMT2 Induces Stemness and Progression of Head and Neck Cancer
por: Jin, Yanli, et al.
Publicado: (2022)

Design of the BRISC study: a multicentre controlled clinical trial to optimize the communication of breast cancer risks in genetic counselling
por: Ockhuysen-Vermey, Caroline F, et al.
Publicado: (2008)

BRISC is required for optimal activation of NF-κB in Kupffer cells induced by LPS and contributes to acute liver injury
por: Zhang, Wen, et al.
Publicado: (2023)

Mechanism of glycogen synthase inactivation and interaction with glycogenin
por: Marr, Laura, et al.
Publicado: (2022)

SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation
por: Paone, A, et al.
Publicado: (2014)

Metformin Is a Pyridoxal-5′-phosphate (PLP)-Competitive Inhibitor of SHMT2
por: Tramonti, Angela, et al.
Publicado: (2021)

Benefits and risks of Iron interventions in children (BRISC): protocol for a three-arm parallel-group randomised controlled field trial in Bangladesh
por: Hasan, Mohammed Imrul, et al.
Publicado: (2017)

SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia
por: García-Cañaveras, Juan C., et al.
Publicado: (2020)

Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis
por: Zeng, Yuanyuan, et al.
Publicado: (2021)

SHMT2 expression as a diagnostic and prognostic marker for thyroid cancer
por: Jin, Meihua, et al.
Publicado: (2021)

Glycyrrhetinic acid restricts mitochondrial energy metabolism by targeting SHMT2
por: Jin, Xiuxiu, et al.
Publicado: (2022)

SHMT1 1420 and MTHFR 677 variants are associated with rectal but not colon cancer
por: Komlósi, Viktor, et al.
Publicado: (2010)

SHMT2 Drives the Progression of Colorectal Cancer by Regulating UHRF1 Expression
por: Cui, Ximao, et al.
Publicado: (2022)

FLOURY ENDOSPERM20 encoding SHMT4 is required for rice endosperm development
por: Yan, Mengyuan, et al.
Publicado: (2022)

Understanding The Regulatory Role of USP32 and SHMT2 in The Progression of Gastric Cancer
por: Li, Jun, et al.
Publicado: (2023)

Pseudokinases-remnants of evolution or key allosteric regulators?
por: Zeqiraj, Elton, et al.
Publicado: (2010)

HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2
por: Cao, Ji, et al.
Publicado: (2019)

Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma
por: Woo, Chern Chiuh, et al.
Publicado: (2016)

Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethal
por: Tani, Haruna, et al.
Publicado: (2018)

SHMT1 inhibits the metastasis of HCC by repressing NOX1-mediated ROS production
por: Dou, Changwei, et al.
Publicado: (2019)

The loss of SHMT2 mediates 5-fluorouracil chemoresistance in colorectal cancer by upregulating autophagy
por: Chen, Jian, et al.
Publicado: (2021)

Combining Transient Expression and Cryo-EM to Obtain High-Resolution Structures of Luteovirid Particles
por: Byrne, Matthew J., et al.
Publicado: (2019)

DNA Binding and Phosphorylation Regulate the Core Structure of the NF-κB p50 Transcription Factor
por: Vonderach, Matthias, et al.
Publicado: (2018)

Proteomic profiling of breast cancer metabolism identifies SHMT2 and ASCT2 as prognostic factors
por: Bernhardt, Stephan, et al.
Publicado: (2017)

Evaluating the clinical significance of SHMT2 and its co-expressed gene in human kidney cancer
por: Wang, Huan, et al.
Publicado: (2020)

Shmt2: A Stat3 Signaling New Player in Prostate Cancer Energy Metabolism
por: Marrocco, Ilaria, et al.
Publicado: (2019)

Identification of SHMT2 as a Potential Prognostic Biomarker and Correlating with Immune Infiltrates in Lung Adenocarcinoma
por: Luo, Lianxiang, et al.
Publicado: (2021)

Cytoplasmic SHMT2 drives the progression and metastasis of colorectal cancer by inhibiting β-catenin degradation
por: Liu, Chunqi, et al.
Publicado: (2021)

SHMT2 regulates serine metabolism to promote the progression and immunosuppression of papillary renal cell carcinoma
por: Kong, Weiyu, et al.
Publicado: (2022)

cAMP-dependent protein kinase (PKA) complexes probed by complementary differential scanning fluorimetry and ion mobility–mass spectrometry
por: Byrne, Dominic P., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_kp7sjjhsa16km0rrocjv1sjibf