GBA mutation promotes early mitochondrial dysfunction in 3D neurosphere models

Glucocerebrosidase (GBA) mutations are the most important genetic risk factor for the development of Parkinson disease (PD). GBA encodes the lysosomal enzyme glucocerebrosidase (GCase). Loss-of-GCase activity in cellular models has implicated lysosomal and mitochondrial dysfunction in PD disease pat...

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Detalles Bibliográficos
Autores principales: Morén, Constanza, Juárez-Flores, Diana Luz, Chau, Kai-Yin, Gegg, Matthew, Garrabou, Glòria, González-Casacuberta, Ingrid, Guitart-Mampel, Mariona, Tolosa, Eduardo, Martí, María José, Cardellach, Francesc, Schapira, Anthony Henry Vernon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914435/
https://www.ncbi.nlm.nih.gov/pubmed/31751314
http://dx.doi.org/10.18632/aging.102460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914435/
https://www.ncbi.nlm.nih.gov/pubmed/31751314
http://dx.doi.org/10.18632/aging.102460

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