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GBA mutation promotes early mitochondrial dysfunction in 3D neurosphere models
Glucocerebrosidase (GBA) mutations are the most important genetic risk factor for the development of Parkinson disease (PD). GBA encodes the lysosomal enzyme glucocerebrosidase (GCase). Loss-of-GCase activity in cellular models has implicated lysosomal and mitochondrial dysfunction in PD disease pat...
Autores principales: | Morén, Constanza, Juárez-Flores, Diana Luz, Chau, Kai-Yin, Gegg, Matthew, Garrabou, Glòria, González-Casacuberta, Ingrid, Guitart-Mampel, Mariona, Tolosa, Eduardo, Martí, María José, Cardellach, Francesc, Schapira, Anthony Henry Vernon |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914435/ https://www.ncbi.nlm.nih.gov/pubmed/31751314 http://dx.doi.org/10.18632/aging.102460 |
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