Structural Dynamics Behind Clinical Mutants of PncA-Asp12Ala, Pro54Leu, and His57Pro of Mycobacterium tuberculosis Associated With Pyrazinamide Resistance

Pyrazinamide (PZA) is one of the main FDA approved drugs to be used as the first line of defense against Mycobacterium Tuberculosis (MTB). It is activated into pyrazinoic acid (POA) via MTB's pncA gene-encoded pyrazinamidase (PZase). Mutations are most commonly responsible for PZA-resistance in...

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Detalles Bibliográficos
Autores principales: Mehmood, Aamir, Khan, Muhammad Tahir, Kaushik, Aman Chandra, Khan, Anwar Sheed, Irfan, Muhammad, Wei, Dong-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914729/
https://www.ncbi.nlm.nih.gov/pubmed/31921809
http://dx.doi.org/10.3389/fbioe.2019.00404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914729/
https://www.ncbi.nlm.nih.gov/pubmed/31921809
http://dx.doi.org/10.3389/fbioe.2019.00404

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