Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives

Mammalian Sirtuin 6 (Sirt6) is an NAD(+)-dependent protein deacylase regulating metabolism and chromatin homeostasis. Sirt6 activation protects against metabolic and aging-related diseases, and Sirt6 inhibition is considered a cancer therapy. Available Sirt6 modulators show insufficient potency and...

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Detalles Bibliográficos
Autores principales: You, Weijie, Zheng, Wei, Weiss, Sandra, Chua, Katrin F., Steegborn, Clemens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914789/
https://www.ncbi.nlm.nih.gov/pubmed/31844103
http://dx.doi.org/10.1038/s41598-019-55654-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914789/
https://www.ncbi.nlm.nih.gov/pubmed/31844103
http://dx.doi.org/10.1038/s41598-019-55654-1

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