Functional importance of NUDT9H domain and N-terminal ADPR-binding pocket in two species variants of vertebrate TRPM2 channels

There are at least two different principles of how ADP-ribose (ADPR) induces activation of TRPM2 channels. In human TRPM2, gating requires the C-terminal NUDT9H domain as ADPR-binding module, whereas in sea anemone, NUDT9H is dispensable and binding of ADPR occurs N-terminally. Zebrafish TRPM2 needs...

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Detalles Bibliográficos
Autores principales: Kühn, Frank J. P., Ehrlich, Wiebke, Barth, Daniel, Kühn, Cornelia, Lückhoff, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914804/
https://www.ncbi.nlm.nih.gov/pubmed/31844070
http://dx.doi.org/10.1038/s41598-019-55232-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914804/
https://www.ncbi.nlm.nih.gov/pubmed/31844070
http://dx.doi.org/10.1038/s41598-019-55232-5

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