Tetramethylpyrazine Attenuates the Endotheliotoxicity and the Mitochondrial Dysfunction by Doxorubicin via 14-3-3γ/Bcl-2

Doxorubicin (Dox) with cardiotoxicity and endotheliotoxicity limits its clinical application for cancer. The toxicitic mechanism involves excess ROS generation. 14-3-3s have the protective effects on various injured tissues and cells. Tetramethylpyrazine (TMP) is an alkaloid extracted from the rhizo...

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Detalles Bibliográficos
Autores principales: Yang, Bin, Li, Hongwei, Qiao, Yang, Zhou, Qing, Chen, Shuping, Yin, Dong, He, Huan, He, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914960/
https://www.ncbi.nlm.nih.gov/pubmed/31885804
http://dx.doi.org/10.1155/2019/5820415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914960/
https://www.ncbi.nlm.nih.gov/pubmed/31885804
http://dx.doi.org/10.1155/2019/5820415

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