Cargando…

Tetramethylpyrazine Attenuates the Endotheliotoxicity and the Mitochondrial Dysfunction by Doxorubicin via 14-3-3γ/Bcl-2

Doxorubicin (Dox) with cardiotoxicity and endotheliotoxicity limits its clinical application for cancer. The toxicitic mechanism involves excess ROS generation. 14-3-3s have the protective effects on various injured tissues and cells. Tetramethylpyrazine (TMP) is an alkaloid extracted from the rhizo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Bin, Li, Hongwei, Qiao, Yang, Zhou, Qing, Chen, Shuping, Yin, Dong, He, Huan, He, Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914960/ https://www.ncbi.nlm.nih.gov/pubmed/31885804 http://dx.doi.org/10.1155/2019/5820415

Ejemplares similares

Doxorubicin Induces Endotheliotoxicity and Mitochondrial Dysfunction via ROS/eNOS/NO Pathway
por: He, Huan, et al.
Publicado: (2020)

Vinegar/Tetramethylpyrazine Induces Nutritional Preconditioning Protecting the Myocardium Mediated by VDAC1
por: He, Huan, et al.
Publicado: (2021)

Capsaicin protects cardiomyocytes against lipopolysaccharide-induced damage via 14-3-3γ-mediated autophagy augmentation
por: Qiao, Yang, et al.
Publicado: (2021)

Capsaicin Alleviates the Deteriorative Mitochondrial Function by Upregulating 14-3-3η in Anoxic or Anoxic/Reoxygenated Cardiomyocytes
por: Qiao, Yang, et al.
Publicado: (2020)

Berberine Inhibits Doxorubicin-Triggered Cardiomyocyte Apoptosis via Attenuating Mitochondrial Dysfunction and Increasing Bcl-2 Expression
por: Lv, Xiuxiu, et al.
Publicado: (2012)

Tetramethylpyrazine Ameliorates High Glucose-Induced Endothelial Dysfunction by Increasing Mitochondrial Biogenesis
por: Xu, Qiong, et al.
Publicado: (2014)

Tanshinone IIA Pretreatment Protects H9c2 Cells against Anoxia/Reoxygenation Injury: Involvement of the Translocation of Bcl-2 to Mitochondria Mediated by 14-3-3η
por: Zhang, Zeyu, et al.
Publicado: (2018)

Tetramethylpyrazine inhibits proliferation of colon cancer cells in vitro
por: Li, Hua, et al.
Publicado: (2021)

Tetramethylpyrazine attenuates periorbital allodynia and neuroinflammation in a model of traumatic brain injury
por: Wang, Zhijing, et al.
Publicado: (2017)

Selective suppression of the JNK-MMP2/9 signal pathway by tetramethylpyrazine attenuates neuropathic pain in rats
por: Jiang, Lai, et al.
Publicado: (2017)

Tetramethylpyrazine attenuates spinal cord ischemic injury due to aortic cross-clamping in rabbits
por: Chen, Shaoyang, et al.
Publicado: (2002)

Epigallocatechin-3-gallate pretreatment alleviates doxorubicin-induced ferroptosis and cardiotoxicity by upregulating AMPKα2 and activating adaptive autophagy
por: He, Huan, et al.
Publicado: (2021)

SIRT1 activation by 2,3,5,6-tetramethylpyrazine alleviates neuroinflammation via inhibiting M1 microglia polarization
por: Chen, Yu, et al.
Publicado: (2023)

Tetramethylpyrazine Retards the Progression and Fibrogenesis of Endometriosis
por: Huang, Shenghui, et al.
Publicado: (2022)

Tetramethylpyrazine: A Review of Its Antitumor Potential and Mechanisms
por: Yang, Shaojie, et al.
Publicado: (2021)

Tetramethylpyrazine in Chinese baijiu: Presence, analysis, formation, and regulation
por: Shi, Xiaoshan, et al.
Publicado: (2022)

Tetramethylpyrazine inhibits CTGF and Smad2/3 expression and proliferation of hepatic stellate cells
por: Li, Jun, et al.
Publicado: (2015)

Tetramethylpyrazine attenuated bupivacaine-induced neurotoxicity in SH-SY5Y cells through regulating apoptosis, autophagy and oxidative damage
por: Wang, Shouliang, et al.
Publicado: (2019)

Tetramethylpyrazine (TMP), an Active Ingredient of Chinese Herb Medicine Chuanxiong, Attenuates the Degeneration of Trabecular Meshwork through SDF-1/CXCR4 Axis
por: Yu, Na, et al.
Publicado: (2015)

Tetramethylpyrazine alleviates endoplasmic reticulum stress-activated apoptosis and related inflammation in chondrocytes
por: Hu, Shuai, et al.
Publicado: (2022)

Luteolin attenuates doxorubicin-induced cardiotoxicity by modulating the PHLPP1/AKT/Bcl-2 signalling pathway
por: Zhang, YanDong, et al.
Publicado: (2020)

Inhibition of miR-128-3p Attenuated Doxorubicin-Triggered Acute Cardiac Injury in Mice by the Regulation of PPAR-γ
por: Zhang, Wen-Bin, et al.
Publicado: (2021)

Tetramethylpyrazine alleviates acute kidney injury by inhibiting NLRP3/HIF-1α and apoptosis
por: Sun, Wangnan, et al.
Publicado: (2020)

rocF affects the production of tetramethylpyrazine in fermented soybeans with Bacillus subtilis BJ3-2
por: Liu, Zhenli, et al.
Publicado: (2022)

Dexmedetomidine attenuates the neuroinflammation and cognitive dysfunction in aged mice by targeting the SNHG14/miR‑340/NF‑κB axis
por: He, Guangbao, et al.
Publicado: (2023)

Efficacy and safety of tetramethylpyrazine phosphate on pulmonary hypertension: study protocol for a randomized controlled study
por: Chen, Yuqin, et al.
Publicado: (2019)

Regulatory mechanisms of tetramethylpyrazine on central nervous system diseases: A review
por: Liu, Yue, et al.
Publicado: (2022)

Emerging roles of 14-3-3γ in the brain disorder
por: Cho, Eunsil, et al.
Publicado: (2020)

Tetramethylpyrazine Protects Endothelial Injury and Antithrombosis via Antioxidant and Antiapoptosis in HUVECs and Zebrafish
por: Zhang, Yafang, et al.
Publicado: (2022)

Protective Effect of Tetramethylpyrazine on Myocardial Ischemia-Reperfusion Injury
por: Qian, Weidong, et al.
Publicado: (2014)

Tetramethylpyrazine promotes the proliferation and migration of brain endothelial cells
por: ZHANG, MINGSHUN, et al.
Publicado: (2014)

Antagonistic Effects of Tetramethylpyrazine on Hypoxic Respiratory Depression in Rats
por: Li, Li, et al.
Publicado: (2020)

Role of the ROS/AMPK signaling pathway in tetramethylpyrazine-induced apoptosis in gastric cancer cells
por: YI, BO, et al.
Publicado: (2013)

A novel Danshensu/tetramethylpyrazine protects against Myocardial Ischemia Reperfusion Injury in rats
por: Wang, Jinghao, et al.
Publicado: (2021)

Correction to: Efficacy and safety of tetramethylpyrazine phosphate on pulmonary hypertension: study protocol for a randomized controlled study
por: Chen, Yuqin, et al.
Publicado: (2020)

Inhibition of Angiogenesis, Fibrosis and Thrombosis by Tetramethylpyrazine: Mechanisms Contributing to the SDF-1/CXCR4 Axis
por: Cai, Xiaoxiao, et al.
Publicado: (2014)

Increasing Yield of 2,3,5,6-Tetramethylpyrazine in Baijiu Through Saccharomyces cerevisiae Metabolic Engineering
por: Cui, Dan-Yao, et al.
Publicado: (2020)

Intraocular administration of tetramethylpyrazine hydrochloride to rats: a direct delivery pathway for brain targeting?
por: Mao, Dan, et al.
Publicado: (2019)

Tetramethylpyrazine-mediated regulation of CXCR4 in retinoblastoma is sensitive to cell density
por: Wu, Nandan, et al.
Publicado: (2017)

Tetramethylpyrazine and Paeoniflorin Synergistically Attenuate Cholesterol Efflux in Macrophage Cells via Enhancing ABCA1 and ABCG1 Expression
por: Mei, Jun, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_55819sg7m1t4b8qdqb3ok4b4or