Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity

The translation initiation repressor 4E-BP2 is deamidated in the brain on asparagines N99/N102 during early postnatal brain development. This post-translational modification enhances 4E-BP2 association with Raptor, a central component of mTORC1 and alters the kinetics of excitatory synaptic transmis...

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Detalles Bibliográficos
Autores principales: Kouloulia, Stella, Hallin, Erik I., Simbriger, Konstanze, Amorim, Inês S., Lach, Gilliard, Amvrosiadis, Theoklitos, Chalkiadaki, Kleanthi, Kampaite, Agniete, Truong, Vinh Tai, Hooshmandi, Mehdi, Jafarnejad, Seyed Mehdi, Skehel, Paul, Kursula, Petri, Khoutorsky, Arkady, Gkogkas, Christos G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915327/
https://www.ncbi.nlm.nih.gov/pubmed/31825840
http://dx.doi.org/10.1016/j.celrep.2019.11.023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915327/
https://www.ncbi.nlm.nih.gov/pubmed/31825840
http://dx.doi.org/10.1016/j.celrep.2019.11.023

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