Assessing average somatic CAG repeat instability at the protein level

Sandwich ELISA-based methods use Abs that target the expanded polyglutamine (polyQ) tract to quantify mutant huntingtin (mHTT). Using Meso Scale Discovery (MSD) assay, the mHTT signal detected with MW1 Ab correlated with polyQ length and doubled with a difference of only 7 glutamine residues between...

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Detalles Bibliográficos
Autores principales: Aviolat, Hubert, Pinto, Ricardo Mouro, Godschall, Elizabeth, Murtha, Ryan, Richey, Hannah E., Sapp, Ellen, Vodicka, Petr, Wheeler, Vanessa C., Kegel-Gleason, Kimberly B., DiFiglia, Marian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915696/
https://www.ncbi.nlm.nih.gov/pubmed/31844074
http://dx.doi.org/10.1038/s41598-019-55202-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915696/
https://www.ncbi.nlm.nih.gov/pubmed/31844074
http://dx.doi.org/10.1038/s41598-019-55202-x

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