Cargando…

Assessing average somatic CAG repeat instability at the protein level

Sandwich ELISA-based methods use Abs that target the expanded polyglutamine (polyQ) tract to quantify mutant huntingtin (mHTT). Using Meso Scale Discovery (MSD) assay, the mHTT signal detected with MW1 Ab correlated with polyQ length and doubled with a difference of only 7 glutamine residues between...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aviolat, Hubert, Pinto, Ricardo Mouro, Godschall, Elizabeth, Murtha, Ryan, Richey, Hannah E., Sapp, Ellen, Vodicka, Petr, Wheeler, Vanessa C., Kegel-Gleason, Kimberly B., DiFiglia, Marian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915696/ https://www.ncbi.nlm.nih.gov/pubmed/31844074 http://dx.doi.org/10.1038/s41598-019-55202-x

Ejemplares similares

Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington’s Disease
por: Tousley, Adelaide, et al.
Publicado: (2019)

Huntingtin associates with the actin cytoskeleton and α-actinin isoforms to influence stimulus dependent morphology changes
por: Tousley, Adelaide, et al.
Publicado: (2019)

Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HD(Q175/Q7) Mice
por: Vodicka, Petr, et al.
Publicado: (2016)

Quantification of Age-Dependent Somatic CAG Repeat Instability in Hdh CAG Knock-In Mice Reveals Different Expansion Dynamics in Striatum and Liver
por: Lee, Jong-Min, et al.
Publicado: (2011)

Early whole-body mutant huntingtin lowering averts changes in proteins and lipids important for synapse function and white matter maintenance in the LacQ140 mouse model
por: Shing, Kai, et al.
Publicado: (2023)

Disposition of Proteins and Lipids in Synaptic Membrane Compartments Is Altered in Q175/Q7 Huntington’s Disease Mouse Striatum
por: Iuliano, Maria, et al.
Publicado: (2021)

Glucose transporter 3 is a rab11-dependent trafficking cargo and its transport to the cell surface is reduced in neurons of CAG140 Huntington’s disease mice
por: McClory, Hollis, et al.
Publicado: (2014)

The COOH-terminal domain of huntingtin interacts with RhoGEF kalirin and modulates cell survival
por: McClory, Hollis, et al.
Publicado: (2018)

Genetic Contributors to Intergenerational CAG Repeat Instability in Huntington’s Disease Knock-In Mice
por: Neto, João Luís, et al.
Publicado: (2017)

Transcription Elongation and Tissue-Specific Somatic CAG Instability
por: Goula, Agathi-Vasiliki, et al.
Publicado: (2012)

Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington’s disease knock-in mice is blocked by Mlh1 knock-out
por: Loupe, Jacob M, et al.
Publicado: (2020)

Modifiers of CAG/CTG Repeat Instability: Insights from Mammalian Models
por: Wheeler, Vanessa C., et al.
Publicado: (2021)

Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice
por: Kovalenko, Marina, et al.
Publicado: (2020)

PMS1 as a target for splice modulation to prevent somatic CAG repeat expansion in Huntington’s disease
por: McLean, Zachariah L., et al.
Publicado: (2023)

Kalirin Interacts with TRAPP and Regulates Rab11 and Endosomal Recycling
por: Wang, Xiaolong, et al.
Publicado: (2020)

CAG·CTG repeat instability in cultured human astrocytes
por: Farrell, Brian T., et al.
Publicado: (2006)

Approaches to Sequence the HTT CAG Repeat Expansion and Quantify Repeat Length Variation
por: Ciosi, Marc, et al.
Publicado: (2021)

Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice
por: Møllersen, Linda, et al.
Publicado: (2012)

Patterns of CAG repeat instability in the central nervous system and periphery in Huntington’s disease and in spinocerebellar ataxia type 1
por: Mouro Pinto, Ricardo, et al.
Publicado: (2020)

Stoichiometry of Base Excision Repair Proteins Correlates with Increased Somatic CAG Instability in Striatum over Cerebellum in Huntington's Disease Transgenic Mice
por: Goula, Agathi-Vassiliki, et al.
Publicado: (2009)

Somatic CAG expansion in Huntington's disease is dependent on the MLH3 endonuclease domain, which can be excluded via splice redirection
por: Roy, Jennie C L, et al.
Publicado: (2021)

Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington’s disease models
por: Conroy, Faith, et al.
Publicado: (2022)

Replication dependent instability at (CTG)•(CAG) repeat hairpins in human cells
por: Liu, Guoqi, et al.
Publicado: (2010)

Instability of (CTG)(n)•(CAG)(n )trinucleotide repeats and DNA synthesis
por: Liu, Guoqi, et al.
Publicado: (2012)

Modifiers of Somatic Repeat Instability in Mouse Models of Friedreich Ataxia and the Fragile X-Related Disorders: Implications for the Mechanism of Somatic Expansion in Huntington’s Disease
por: Zhao, Xiaonan, et al.
Publicado: (2021)

Somatic CTG•CAG repeat instability in a mouse model for myotonic dystrophy type 1 is associated with changes in cell nuclearity and DNA ploidy
por: van den Broek, Walther JAA, et al.
Publicado: (2007)

Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington’s disease
por: O’Reilly, Daniel, et al.
Publicado: (2023)

GFP-Based Fluorescence Assay for CAG Repeat Instability in Cultured Human Cells
por: Santillan, Beatriz A., et al.
Publicado: (2014)

CAG Somatic Instability in a Huntington Disease Expansion Carrier Presenting with a Progressive Supranuclear Palsy‐like Phenotype
por: Dewan, Ramita, et al.
Publicado: (2022)

Problems and solutions for the analysis of somatic CAG repeat expansion and their relationship to Huntington's disease toxicity
por: Budworth, Helen, et al.
Publicado: (2016)

Mismatch Repair Genes Mlh1 and Mlh3 Modify CAG Instability in Huntington's Disease Mice: Genome-Wide and Candidate Approaches
por: Pinto, Ricardo Mouro, et al.
Publicado: (2013)

Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors
por: Kegel, Kimberly B, et al.
Publicado: (2010)

Hippo Signaling Pathway Dysregulation in Human Huntington’s Disease Brain and Neuronal Stem Cells
por: Mueller, Kaly A., et al.
Publicado: (2018)

Minimizing carry-over PCR contamination in expanded CAG/CTG repeat instability applications
por: Aeschbach, Lorène, et al.
Publicado: (2017)

CAG Repeat Instability in the Peripheral and Central Nervous System of Transgenic Huntington’s Disease Monkeys
por: Cho, In K., et al.
Publicado: (2022)

The Contribution of Somatic Expansion of the CAG Repeat to Symptomatic Development in Huntington’s Disease: A Historical Perspective
por: Monckton, Darren G.
Publicado: (2021)

In Vitro Expansion of CAG, CAA, and Mixed CAG/CAA Repeats
por: Figura, Grzegorz, et al.
Publicado: (2015)

MSH2 ATPase Domain Mutation Affects CTG•CAG Repeat Instability in Transgenic Mice
por: Tomé, Stéphanie, et al.
Publicado: (2009)

MSH3 Polymorphisms and Protein Levels Affect CAG Repeat Instability in Huntington's Disease Mice
por: Tomé, Stéphanie, et al.
Publicado: (2013)

Effects of Anthocyanins on CAG Repeat Instability and Behaviour in Huntington’s Disease R6/1 Mice
por: Møllersen, Linda, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_dg7h47sdetim1np1ebpc7am70q