Damaging coding variants within kainate receptor channel genes are enriched in individuals with schizophrenia, autism and intellectual disabilities

Schizophrenia (Scz), autism spectrum disorder (ASD) and intellectual disability are common complex neurodevelopmental disorders. Kainate receptors (KARs) are ionotropic glutamate ion channels involved in synaptic plasticity which are modulated by auxiliary NETO proteins. Using UK10K exome sequencing...

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Detalles Bibliográficos
Autores principales: Koromina, Maria, Flitton, Miles, Blockley, Alix, Mellor, Ian R., Knight, Helen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915710/
https://www.ncbi.nlm.nih.gov/pubmed/31844109
http://dx.doi.org/10.1038/s41598-019-55635-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915710/
https://www.ncbi.nlm.nih.gov/pubmed/31844109
http://dx.doi.org/10.1038/s41598-019-55635-4

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