Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease

A key knowledge gap blocking development of effective therapeutics for Alzheimer’s disease (AD) is the lack of understanding of how amyloid beta (Aβ) peptide and pathological forms of the tau protein cooperate in causing disease phenotypes. Within a mouse tau-deficient background, we probed the mole...

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Detalles Bibliográficos
Autores principales: Pickett, Eleanor K., Herrmann, Abigail G., McQueen, Jamie, Abt, Kimberly, Dando, Owen, Tulloch, Jane, Jain, Pooja, Dunnett, Sophie, Sohrabi, Sadaf, Fjeldstad, Maria P., Calkin, Will, Murison, Leo, Jackson, Rosemary J., Tzioras, Makis, Stevenson, Anna, d’Orange, Marie, Hooley, Monique, Davies, Caitlin, Colom-Cadena, Marti, Anton-Fernandez, Alejandro, King, Declan, Oren, Iris, Rose, Jamie, McKenzie, Chris-Anne, Allison, Elizabeth, Smith, Colin, Hardt, Oliver, Henstridge, Christopher M., Hardingham, Giles E., Spires-Jones, Tara L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915767/
https://www.ncbi.nlm.nih.gov/pubmed/31825838
http://dx.doi.org/10.1016/j.celrep.2019.11.044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915767/
https://www.ncbi.nlm.nih.gov/pubmed/31825838
http://dx.doi.org/10.1016/j.celrep.2019.11.044

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