A genome-scale CRISPR/Cas9 knockout screening reveals SH3D21 as a sensitizer for gemcitabine

Gemcitabine, 2′,2′-difluoro-2′-deoxycytidine, is used as a pro-drug in treatment of variety of solid tumour cancers including pancreatic cancer. After intake, gemcitabine is transferred to the cells by the membrane nucleoside transporter proteins. Once inside the cells, it is converted to gemcitabin...

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Detalles Bibliográficos
Autores principales: Masoudi, Mohammad, Seki, Motoaki, Yazdanparast, Razieh, Yachie, Nozomu, Aburatani, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915784/
https://www.ncbi.nlm.nih.gov/pubmed/31844142
http://dx.doi.org/10.1038/s41598-019-55893-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915784/
https://www.ncbi.nlm.nih.gov/pubmed/31844142
http://dx.doi.org/10.1038/s41598-019-55893-2

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