Genetic Deletion of Hesx1 Promotes Exit from the Pluripotent State and Impairs Developmental Diapause

The role of the homeobox transcriptional repressor HESX1 in embryonic stem cells (ESCs) remains mostly unknown. Here, we show that Hesx1 is expressed in the preimplantation mouse embryo, where it is required during developmental diapause. Absence of Hesx1 leads to reduced expression of epiblast and...

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Detalles Bibliográficos
Autores principales: Pozzi, Sara, Bowling, Sarah, Apps, John, Brickman, Joshua M., Rodriguez, Tristan A., Martinez-Barbera, Juan Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915801/
https://www.ncbi.nlm.nih.gov/pubmed/31761678
http://dx.doi.org/10.1016/j.stemcr.2019.10.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915801/
https://www.ncbi.nlm.nih.gov/pubmed/31761678
http://dx.doi.org/10.1016/j.stemcr.2019.10.014

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