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SOX21 Ensures Rostral Forebrain Identity by Suppression of WNT8B during Neural Regionalization of Human Embryonic Stem Cells

The generation of brain region-specific progenitors from human embryonic stem cells (hESCs) is critical for their application. However, transcriptional regulation of neural regionalization in humans is poorly understood. Here, we applied a rostrocaudal patterning system from hESCs to dissect global...

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Detalles Bibliográficos
Autores principales: Fang, Zhuoqing, Liu, Xinyuan, Wen, Jing, Tang, Fan, Zhou, Yang, Jing, Naihe, Jin, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915843/
https://www.ncbi.nlm.nih.gov/pubmed/31761677
http://dx.doi.org/10.1016/j.stemcr.2019.10.013