Reprogramming of Fibroblasts to Oligodendrocyte Progenitor-like Cells Using CRISPR/Cas9-Based Synthetic Transcription Factors

Cell lineage reprogramming via transgene overexpression of key master regulatory transcription factors has been well documented. However, the poor efficiency and lack of fidelity of this approach is problematic. Synthetic transcription factors (sTFs)—built from the repurposed CRISPR/Cas9 system—can...

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Detalles Bibliográficos
Autores principales: Matjusaitis, Mantas, Wagstaff, Laura J., Martella, Andrea, Baranowski, Bart, Blin, Carla, Gogolok, Sabine, Williams, Anna, Pollard, Steven M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915844/
https://www.ncbi.nlm.nih.gov/pubmed/31708478
http://dx.doi.org/10.1016/j.stemcr.2019.10.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915844/
https://www.ncbi.nlm.nih.gov/pubmed/31708478
http://dx.doi.org/10.1016/j.stemcr.2019.10.010

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