Systematic underestimation of the epigenetic clock and age acceleration in older subjects

BACKGROUND: The Horvath epigenetic clock is widely used. It predicts age quite well from 353 CpG sites in the DNA methylation profile in unknown samples and has been used to calculate “age acceleration” in various tissues and environments. RESULTS: The model systematically underestimates age in tiss...

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Detalles Bibliográficos
Autores principales: El Khoury, Louis Y., Gorrie-Stone, Tyler, Smart, Melissa, Hughes, Amanda, Bao, Yanchun, Andrayas, Alexandria, Burrage, Joe, Hannon, Eilis, Kumari, Meena, Mill, Jonathan, Schalkwyk, Leonard C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915902/
https://www.ncbi.nlm.nih.gov/pubmed/31847916
http://dx.doi.org/10.1186/s13059-019-1810-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915902/
https://www.ncbi.nlm.nih.gov/pubmed/31847916
http://dx.doi.org/10.1186/s13059-019-1810-4

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