Cargando…

Systematic underestimation of the epigenetic clock and age acceleration in older subjects

BACKGROUND: The Horvath epigenetic clock is widely used. It predicts age quite well from 353 CpG sites in the DNA methylation profile in unknown samples and has been used to calculate “age acceleration” in various tissues and environments. RESULTS: The model systematically underestimates age in tiss...

Descripción completa

Detalles Bibliográficos
Autores principales:	El Khoury, Louis Y., Gorrie-Stone, Tyler, Smart, Melissa, Hughes, Amanda, Bao, Yanchun, Andrayas, Alexandria, Burrage, Joe, Hannon, Eilis, Kumari, Meena, Mill, Jonathan, Schalkwyk, Leonard C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915902/ https://www.ncbi.nlm.nih.gov/pubmed/31847916 http://dx.doi.org/10.1186/s13059-019-1810-4

Ejemplares similares

Social mobility across the lifecourse and DNA methylation age acceleration in adults in the UK
por: Bao, Yanchun, et al.
Publicado: (2022)

Socioeconomic Position and DNA Methylation Age Acceleration Across the Life Course
por: Hughes, Amanda, et al.
Publicado: (2018)

Leveraging DNA-Methylation Quantitative-Trait Loci to Characterize the Relationship between Methylomic Variation, Gene Expression, and Complex Traits
por: Hannon, Eilis, et al.
Publicado: (2018)

Bigmelon: tools for analysing large DNA methylation datasets
por: Gorrie-Stone, Tyler J, et al.
Publicado: (2019)

Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array
por: Mansell, Georgina, et al.
Publicado: (2019)

Evaluation of nanopore sequencing for epigenetic epidemiology: a comparison with DNA methylation microarrays
por: Flynn, Robert, et al.
Publicado: (2022)

Uncertainty quantification of reference-based cellular deconvolution algorithms
por: Vellame, Dorothea Seiler, et al.
Publicado: (2022)

Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex
por: Shireby, Gemma L, et al.
Publicado: (2020)

DNA methylation-based sex classifier to predict sex and identify sex chromosome aneuploidy
por: Wang, Yucheng, et al.
Publicado: (2021)

Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes
por: Hannon, Eilis, et al.
Publicado: (2015)

InterpolatedXY: a two-step strategy to normalize DNA methylation microarray data avoiding sex bias
por: Wang, Yucheng, et al.
Publicado: (2022)

Genetic risk variants for brain disorders are enriched in cortical H3K27ac domains
por: Hannon, Eilis, et al.
Publicado: (2019)

Variation in 5-hydroxymethylcytosine across human cortex and cerebellum
por: Lunnon, Katie, et al.
Publicado: (2016)

Erratum to: Variation in 5-hydroxymethylcytosine across human cortex and cerebellum
por: Lunnon, Katie, et al.
Publicado: (2016)

5-hydroxymethylcytosine is highly dynamic across human fetal brain development
por: Spiers, Helen, et al.
Publicado: (2017)

Methylation age acceleration does not predict mortality in schizophrenia
por: Kowalec, Kaarina, et al.
Publicado: (2019)

Methylation quantitative trait loci in the developing brain and their enrichment in schizophrenia-associated genomic regions
por: Hannon, Eilis, et al.
Publicado: (2015)

Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons
por: Steg, Leonard C., et al.
Publicado: (2021)

Major surgery induces acute changes in measured DNA methylation associated with immune response pathways
por: Sadahiro, Ryoichi, et al.
Publicado: (2020)

Assessing the co-variability of DNA methylation across peripheral cells and tissues: Implications for the interpretation of findings in epigenetic epidemiology
por: Hannon, Eilis, et al.
Publicado: (2021)

Genome-wide methylomic analysis in individuals with HNF1B intragenic mutation and 17q12 microdeletion
por: Clissold, Rhian L., et al.
Publicado: (2018)

Functional characterization of the schizophrenia associated gene AS3MT identifies a role in neuronal development
por: Washer, Sam J., et al.
Publicado: (2022)

Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer’s disease
por: Smith, Adam R., et al.
Publicado: (2019)

Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue
por: Devall, Matthew, et al.
Publicado: (2017)

An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation
por: Hannon, Eilis, et al.
Publicado: (2016)

Genome-wide characterization of mitochondrial DNA methylation in human brain
por: Devall, Matthew, et al.
Publicado: (2023)

Methylomic trajectories across human fetal brain development
por: Spiers, Helen, et al.
Publicado: (2015)

Does the feedback of blood results in observational studies influence response and consent? A randomised study of the Understanding Society Innovation Panel
por: Benzeval, Michaela, et al.
Publicado: (2023)

Genetic architecture of epigenetic and neuronal ageing rates in human brain regions
por: Lu, Ake T., et al.
Publicado: (2017)

Genome-wide DNA methylation meta-analysis in the brains of suicide completers
por: Policicchio, Stefania, et al.
Publicado: (2020)

Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia
por: Pidsley, Ruth, et al.
Publicado: (2014)

Methylomic markers of persistent childhood asthma: a longitudinal study of asthma-discordant monozygotic twins
por: Murphy, Therese M., et al.
Publicado: (2015)

Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins
por: Hannon, Eilis, et al.
Publicado: (2018)

Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum
por: Lu, Ake T., et al.
Publicado: (2016)

Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions
por: Viana, Joana, et al.
Publicado: (2017)

Epigenetic Clocks Are Not Accelerated in COVID-19 Patients
por: Franzen, Julia, et al.
Publicado: (2021)

Cross-tissue methylomic profiling strongly implicates a role for cortex-specific deregulation of ANK1 in Alzheimer’s disease neuropathology
por: Lunnon, Katie, et al.
Publicado: (2014)

A randomised study of nurse collected venous blood and self-collected dried blood spots for the assessment of cardiovascular risk factors in the Understanding Society Innovation Panel
por: Kumari, Meena, et al.
Publicado: (2023)

Pleiotropic Effects of Trait-Associated Genetic Variation on DNA Methylation: Utility for Refining GWAS Loci
por: Hannon, Eilis, et al.
Publicado: (2017)

Characterizing the properties of bisulfite sequencing data: maximizing power and sensitivity to identify between-group differences in DNA methylation
por: Seiler Vellame, Dorothea, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ql9m1rl99qo1rtnqd1f272lid2