Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain

Hexanucleotide repeat expansions of variable size in C9orf72 are the most prevalent genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Sense and antisense transcripts of the expansions are translated by repeat-associated non-AUG translation into five dipeptide repeat protein...

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Detalles Bibliográficos
Autores principales: Morón-Oset, Javier, Supèr, Tessa, Esser, Jacqueline, Isaacs, Adrian M., Grönke, Sebastian, Partridge, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916080/
https://www.ncbi.nlm.nih.gov/pubmed/31843021
http://dx.doi.org/10.1186/s40478-019-0860-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916080/
https://www.ncbi.nlm.nih.gov/pubmed/31843021
http://dx.doi.org/10.1186/s40478-019-0860-x

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