The double edge of anti-CD40 siRNA therapy: It increases renal microcapillar density but favours the generation of an inflammatory milieu in the kidneys of ApoE(−/−) mice

BACKGROUND: Chronic kidney disease (CKD) is associated with endothelial dysfunctions thus prompting links between microcirculation (MC), inflammation and major cardiovascular risk factors. PURPOSE OF THE STUDY: We have previously reported that siRNA-silencing of CD40 (siCD40) reduced atherosclerosis...

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Detalles Bibliográficos
Autores principales: Hueso, Miguel, Casas, Angela, Mallén, Adrian, de Ramón, Laura, Bolaños, Nuria, Varela, Cristian, Cruzado, Josep M., Torras, Joan, Navarro, Estanislao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916081/
https://www.ncbi.nlm.nih.gov/pubmed/31889910
http://dx.doi.org/10.1186/s12950-019-0228-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916081/
https://www.ncbi.nlm.nih.gov/pubmed/31889910
http://dx.doi.org/10.1186/s12950-019-0228-9

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