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Interactions between Yersinia pestis V-antigen (LcrV) and human Toll-like receptor 2 (TLR2) in a modelled protein complex and potential mechanistic insights

BACKGROUND: Yersinia pestis, the etiological pathogen of plague, is capable of repressing the immune response of white blood cells to evade phagocytosis. The V-antigen (LcrV) was found to be involved in this process by binding to human Toll-like Receptor 2 (TLR2). The detailed mechanism behind this...

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Detalles Bibliográficos
Autores principales: Wei, Tiandi, Gong, Jing, Qu, Guojing, Wang, Mingyu, Xu, Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916237/
https://www.ncbi.nlm.nih.gov/pubmed/31842739
http://dx.doi.org/10.1186/s12865-019-0329-5