Burosumab Improved Histomorphometric Measures of Osteomalacia in Adults with X‐Linked Hypophosphatemia: A Phase 3, Single‐Arm, International Trial

In adults with X‐linked hypophosphatemia (XLH), excess FGF23 impairs renal phosphate reabsorption and suppresses production of 1,25‐dihydroxyvitamin D, resulting in chronic hypophosphatemia and persistent osteomalacia. Osteomalacia is associated with poor bone quality causing atraumatic fractures, p...

Descripción completa

Detalles Bibliográficos
Autores principales: Insogna, Karl L, Rauch, Frank, Kamenický, Peter, Ito, Nobuaki, Kubota, Takuo, Nakamura, Akie, Zhang, Lin, Mealiffe, Matt, San Martin, Javier, Portale, Anthony A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Clinical Trials
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916280/
https://www.ncbi.nlm.nih.gov/pubmed/31369697
http://dx.doi.org/10.1002/jbmr.3843

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916280/
https://www.ncbi.nlm.nih.gov/pubmed/31369697
http://dx.doi.org/10.1002/jbmr.3843

Ejemplares similares