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Aβ oligomers trigger and accelerate Aβ seeding

Aggregation of amyloid‐β (Aβ) that leads to the formation of plaques in Alzheimer's disease (AD) occurs through the stepwise formation of oligomers and fibrils. An earlier onset of aggregation is obtained upon intracerebral injection of Aβ‐containing brain homogenate into human APP transgenic m...

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Detalles Bibliográficos
Autores principales: Katzmarski, Natalie, Ziegler‐Waldkirch, Stephanie, Scheffler, Nina, Witt, Christian, Abou‐Ajram, Claudia, Nuscher, Brigitte, Prinz, Marco, Haass, Christian, Meyer‐Luehmann, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916291/
https://www.ncbi.nlm.nih.gov/pubmed/31099449
http://dx.doi.org/10.1111/bpa.12734