Hydrogen‐deuterium exchange mass spectrometry highlights conformational changes induced by factor XI activation and binding of factor IX to factor XIa

BACKGROUND: Factor XI (FXI) is a zymogen in the coagulation pathway that, once activated, promotes haemostasis by activating factor IX (FIX). Substitution studies using apple domains of the homologous protein prekallikrein have identified that FIX binds to the apple 3 domain of FXI. However, the mol...

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Detalles Bibliográficos
Autores principales: Bar Barroeta, Awital, van Galen, Josse, Stroo, Ingrid, Marquart, J. Arnoud, Meijer, Alexander B., Meijers, Joost C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
HAEMOSTASIS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916417/
https://www.ncbi.nlm.nih.gov/pubmed/31519061
http://dx.doi.org/10.1111/jth.14632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916417/
https://www.ncbi.nlm.nih.gov/pubmed/31519061
http://dx.doi.org/10.1111/jth.14632

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