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In vivo conversion of rat astrocytes into neuronal cells through neural stem cells in injured spinal cord with a single zinc-finger transcription factor

BACKGROUND: Spinal cord injury (SCI) results in glial scar formation and irreversible neuronal loss, which finally leads to functional impairments and long-term disability. Our previous studies have demonstrated that the ectopic expression of Zfp521 reprograms fibroblasts and astrocytes into induced...

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Detalles Bibliográficos
Autores principales: Zarei-Kheirabadi, Masoumeh, Hesaraki, Mahdi, Kiani, Sahar, Baharvand, Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916443/
https://www.ncbi.nlm.nih.gov/pubmed/31842989
http://dx.doi.org/10.1186/s13287-019-1448-x