Ligand‐ and Structure‐Based Approaches of Escherichia coli FabI Inhibition by Triclosan Derivatives: From Chemical Similarity to Protein Dynamics Influence

Enoyl‐acyl carrier protein reductase (FabI) is the limiting step to complete the elongation cycle in type II fatty acid synthase (FAS) systems and is a relevant target for antibacterial drugs. E. coli FabI has been employed as a model to develop new inhibitors against FAS, especially triclosan and d...

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Detalles Bibliográficos
Autores principales: Kronenberger, Thales, de Oliveira Fernades, Philipe, Drumond Franco, Isabella, Poso, Antti, Gonçalves Maltarollo, Vinícius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916556/
https://www.ncbi.nlm.nih.gov/pubmed/31670463
http://dx.doi.org/10.1002/cmdc.201900415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916556/
https://www.ncbi.nlm.nih.gov/pubmed/31670463
http://dx.doi.org/10.1002/cmdc.201900415

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