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Loading‐Dependent Structural Model of Polymeric Micelles Encapsulating Curcumin by Solid‐State NMR Spectroscopy

Detailed insight into the internal structure of drug‐loaded polymeric micelles is scarce, but important for developing optimized delivery systems. We observed that an increase in the curcumin loading of triblock copolymers based on poly(2‐oxazolines) and poly(2‐oxazines) results in poorer dissolutio...

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Autores principales: Pöppler, Ann‐Christin, Lübtow, Michael M., Schlauersbach, Jonas, Wiest, Johannes, Meinel, Lorenz, Luxenhofer, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916580/
https://www.ncbi.nlm.nih.gov/pubmed/31529576
http://dx.doi.org/10.1002/anie.201908914
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author Pöppler, Ann‐Christin
Lübtow, Michael M.
Schlauersbach, Jonas
Wiest, Johannes
Meinel, Lorenz
Luxenhofer, Robert
author_facet Pöppler, Ann‐Christin
Lübtow, Michael M.
Schlauersbach, Jonas
Wiest, Johannes
Meinel, Lorenz
Luxenhofer, Robert
author_sort Pöppler, Ann‐Christin
collection PubMed
description Detailed insight into the internal structure of drug‐loaded polymeric micelles is scarce, but important for developing optimized delivery systems. We observed that an increase in the curcumin loading of triblock copolymers based on poly(2‐oxazolines) and poly(2‐oxazines) results in poorer dissolution properties. Using solid‐state NMR spectroscopy and complementary tools we propose a loading‐dependent structural model on the molecular level that provides an explanation for these pronounced differences. Changes in the chemical shifts and cross‐peaks in 2D NMR experiments give evidence for the involvement of the hydrophobic polymer block in the curcumin coordination at low loadings, while at higher loadings an increase in the interaction with the hydrophilic polymer blocks is observed. The involvement of the hydrophilic compartment may be critical for ultrahigh‐loaded polymer micelles and can help to rationalize specific polymer modifications to improve the performance of similar drug delivery systems.
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spelling pubmed-69165802019-12-23 Loading‐Dependent Structural Model of Polymeric Micelles Encapsulating Curcumin by Solid‐State NMR Spectroscopy Pöppler, Ann‐Christin Lübtow, Michael M. Schlauersbach, Jonas Wiest, Johannes Meinel, Lorenz Luxenhofer, Robert Angew Chem Int Ed Engl Communications Detailed insight into the internal structure of drug‐loaded polymeric micelles is scarce, but important for developing optimized delivery systems. We observed that an increase in the curcumin loading of triblock copolymers based on poly(2‐oxazolines) and poly(2‐oxazines) results in poorer dissolution properties. Using solid‐state NMR spectroscopy and complementary tools we propose a loading‐dependent structural model on the molecular level that provides an explanation for these pronounced differences. Changes in the chemical shifts and cross‐peaks in 2D NMR experiments give evidence for the involvement of the hydrophobic polymer block in the curcumin coordination at low loadings, while at higher loadings an increase in the interaction with the hydrophilic polymer blocks is observed. The involvement of the hydrophilic compartment may be critical for ultrahigh‐loaded polymer micelles and can help to rationalize specific polymer modifications to improve the performance of similar drug delivery systems. John Wiley and Sons Inc. 2019-11-04 2019-12-16 /pmc/articles/PMC6916580/ /pubmed/31529576 http://dx.doi.org/10.1002/anie.201908914 Text en © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Communications
Pöppler, Ann‐Christin
Lübtow, Michael M.
Schlauersbach, Jonas
Wiest, Johannes
Meinel, Lorenz
Luxenhofer, Robert
Loading‐Dependent Structural Model of Polymeric Micelles Encapsulating Curcumin by Solid‐State NMR Spectroscopy
title Loading‐Dependent Structural Model of Polymeric Micelles Encapsulating Curcumin by Solid‐State NMR Spectroscopy
title_full Loading‐Dependent Structural Model of Polymeric Micelles Encapsulating Curcumin by Solid‐State NMR Spectroscopy
title_fullStr Loading‐Dependent Structural Model of Polymeric Micelles Encapsulating Curcumin by Solid‐State NMR Spectroscopy
title_full_unstemmed Loading‐Dependent Structural Model of Polymeric Micelles Encapsulating Curcumin by Solid‐State NMR Spectroscopy
title_short Loading‐Dependent Structural Model of Polymeric Micelles Encapsulating Curcumin by Solid‐State NMR Spectroscopy
title_sort loading‐dependent structural model of polymeric micelles encapsulating curcumin by solid‐state nmr spectroscopy
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916580/
https://www.ncbi.nlm.nih.gov/pubmed/31529576
http://dx.doi.org/10.1002/anie.201908914
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