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Loading‐Dependent Structural Model of Polymeric Micelles Encapsulating Curcumin by Solid‐State NMR Spectroscopy
Detailed insight into the internal structure of drug‐loaded polymeric micelles is scarce, but important for developing optimized delivery systems. We observed that an increase in the curcumin loading of triblock copolymers based on poly(2‐oxazolines) and poly(2‐oxazines) results in poorer dissolutio...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916580/ https://www.ncbi.nlm.nih.gov/pubmed/31529576 http://dx.doi.org/10.1002/anie.201908914 |
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author | Pöppler, Ann‐Christin Lübtow, Michael M. Schlauersbach, Jonas Wiest, Johannes Meinel, Lorenz Luxenhofer, Robert |
author_facet | Pöppler, Ann‐Christin Lübtow, Michael M. Schlauersbach, Jonas Wiest, Johannes Meinel, Lorenz Luxenhofer, Robert |
author_sort | Pöppler, Ann‐Christin |
collection | PubMed |
description | Detailed insight into the internal structure of drug‐loaded polymeric micelles is scarce, but important for developing optimized delivery systems. We observed that an increase in the curcumin loading of triblock copolymers based on poly(2‐oxazolines) and poly(2‐oxazines) results in poorer dissolution properties. Using solid‐state NMR spectroscopy and complementary tools we propose a loading‐dependent structural model on the molecular level that provides an explanation for these pronounced differences. Changes in the chemical shifts and cross‐peaks in 2D NMR experiments give evidence for the involvement of the hydrophobic polymer block in the curcumin coordination at low loadings, while at higher loadings an increase in the interaction with the hydrophilic polymer blocks is observed. The involvement of the hydrophilic compartment may be critical for ultrahigh‐loaded polymer micelles and can help to rationalize specific polymer modifications to improve the performance of similar drug delivery systems. |
format | Online Article Text |
id | pubmed-6916580 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69165802019-12-23 Loading‐Dependent Structural Model of Polymeric Micelles Encapsulating Curcumin by Solid‐State NMR Spectroscopy Pöppler, Ann‐Christin Lübtow, Michael M. Schlauersbach, Jonas Wiest, Johannes Meinel, Lorenz Luxenhofer, Robert Angew Chem Int Ed Engl Communications Detailed insight into the internal structure of drug‐loaded polymeric micelles is scarce, but important for developing optimized delivery systems. We observed that an increase in the curcumin loading of triblock copolymers based on poly(2‐oxazolines) and poly(2‐oxazines) results in poorer dissolution properties. Using solid‐state NMR spectroscopy and complementary tools we propose a loading‐dependent structural model on the molecular level that provides an explanation for these pronounced differences. Changes in the chemical shifts and cross‐peaks in 2D NMR experiments give evidence for the involvement of the hydrophobic polymer block in the curcumin coordination at low loadings, while at higher loadings an increase in the interaction with the hydrophilic polymer blocks is observed. The involvement of the hydrophilic compartment may be critical for ultrahigh‐loaded polymer micelles and can help to rationalize specific polymer modifications to improve the performance of similar drug delivery systems. John Wiley and Sons Inc. 2019-11-04 2019-12-16 /pmc/articles/PMC6916580/ /pubmed/31529576 http://dx.doi.org/10.1002/anie.201908914 Text en © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Communications Pöppler, Ann‐Christin Lübtow, Michael M. Schlauersbach, Jonas Wiest, Johannes Meinel, Lorenz Luxenhofer, Robert Loading‐Dependent Structural Model of Polymeric Micelles Encapsulating Curcumin by Solid‐State NMR Spectroscopy |
title | Loading‐Dependent Structural Model of Polymeric Micelles Encapsulating Curcumin by Solid‐State NMR Spectroscopy
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title_full | Loading‐Dependent Structural Model of Polymeric Micelles Encapsulating Curcumin by Solid‐State NMR Spectroscopy
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title_fullStr | Loading‐Dependent Structural Model of Polymeric Micelles Encapsulating Curcumin by Solid‐State NMR Spectroscopy
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title_full_unstemmed | Loading‐Dependent Structural Model of Polymeric Micelles Encapsulating Curcumin by Solid‐State NMR Spectroscopy
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title_short | Loading‐Dependent Structural Model of Polymeric Micelles Encapsulating Curcumin by Solid‐State NMR Spectroscopy
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title_sort | loading‐dependent structural model of polymeric micelles encapsulating curcumin by solid‐state nmr spectroscopy |
topic | Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916580/ https://www.ncbi.nlm.nih.gov/pubmed/31529576 http://dx.doi.org/10.1002/anie.201908914 |
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