Suppression of Ribosomal Pausing by eIF5A Is Necessary to Maintain the Fidelity of Start Codon Selection

Sequences within 5′ UTRs dictate the site and efficiency of translation initiation. In this study, an unbiased screen designed to interrogate the 5′ UTR-mediated regulation of the growth-promoting gene MYC unexpectedly revealed the ribosomal pause relief factor eIF5A as a regulator of translation in...

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Detalles Bibliográficos
Autores principales: Manjunath, Hema, Zhang, He, Rehfeld, Frederick, Han, Jaeil, Chang, Tsung-Cheng, Mendell, Joshua T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917043/
https://www.ncbi.nlm.nih.gov/pubmed/31801078
http://dx.doi.org/10.1016/j.celrep.2019.10.129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917043/
https://www.ncbi.nlm.nih.gov/pubmed/31801078
http://dx.doi.org/10.1016/j.celrep.2019.10.129

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