Herpesviral lytic gene functions render the viral genome susceptible to novel editing by CRISPR/Cas9

Herpes simplex virus (HSV) establishes lifelong latent infection and can cause serious human disease, but current antiviral therapies target lytic but not latent infection. We screened for sgRNAs that cleave HSV-1 DNA sequences efficiently in vitro and used these sgRNAs to observe the first editing...

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Detalles Bibliográficos
Autores principales: Oh, Hyung Suk, Neuhausser, Werner M, Eggan, Pierce, Angelova, Magdalena, Kirchner, Rory, Eggan, Kevin C, Knipe, David M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917492/
https://www.ncbi.nlm.nih.gov/pubmed/31789594
http://dx.doi.org/10.7554/eLife.51662

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917492/
https://www.ncbi.nlm.nih.gov/pubmed/31789594
http://dx.doi.org/10.7554/eLife.51662

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