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Herpesviral lytic gene functions render the viral genome susceptible to novel editing by CRISPR/Cas9
Herpes simplex virus (HSV) establishes lifelong latent infection and can cause serious human disease, but current antiviral therapies target lytic but not latent infection. We screened for sgRNAs that cleave HSV-1 DNA sequences efficiently in vitro and used these sgRNAs to observe the first editing...
Autores principales: | Oh, Hyung Suk, Neuhausser, Werner M, Eggan, Pierce, Angelova, Magdalena, Kirchner, Rory, Eggan, Kevin C, Knipe, David M |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917492/ https://www.ncbi.nlm.nih.gov/pubmed/31789594 http://dx.doi.org/10.7554/eLife.51662 |
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