A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion

CARM1 is a cancer-relevant protein arginine methyltransferase that regulates many aspects of transcription. Its pharmacological inhibition is a promising anti-cancer strategy. Here SKI-73 (6a in this work) is presented as a CARM1 chemical probe with pro-drug properties. SKI-73 (6a) can rapidly penet...

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Detalles Bibliográficos
Autores principales: Cai, Xiao-Chuan, Zhang, Tuo, Kim, Eui-jun, Jiang, Ming, Wang, Ke, Wang, Junyi, Chen, Shi, Zhang, Nawei, Wu, Hong, Li, Fengling, dela Seña, Carlo C, Zeng, Hong, Vivcharuk, Victor, Niu, Xiang, Zheng, Weihong, Lee, Jonghan P, Chen, Yuling, Barsyte, Dalia, Szewczyk, Magda, Hajian, Taraneh, Ibáñez, Glorymar, Dong, Aiping, Dombrovski, Ludmila, Zhang, Zhenyu, Deng, Haiteng, Min, Jinrong, Arrowsmith, Cheryl H, Mazutis, Linas, Shi, Lei, Vedadi, Masoud, Brown, Peter J, Xiang, Jenny, Qin, Li-Xuan, Xu, Wei, Luo, Minkui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917500/
https://www.ncbi.nlm.nih.gov/pubmed/31657716
http://dx.doi.org/10.7554/eLife.47110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917500/
https://www.ncbi.nlm.nih.gov/pubmed/31657716
http://dx.doi.org/10.7554/eLife.47110

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