mTORC1-Rps15 Axis Contributes to the Mechanisms Underlying Global Translation Reduction During Senescence of Mouse Embryonic Fibroblasts

The reduction of protein translation is a common feature in senescent cells and aging organisms, yet the underlying mechanisms are not fully understood. Here we show that both global mRNA translation and mammalian/mechanistic target of rapamycin complex 1 (mTORC1) kinase activity are declined in a s...

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Detalles Bibliográficos
Autores principales: Wu, Su, Xu, Siyao, Li, Ruofei, Li, Kecheng, Zhong, Xiaoqin, Li, Yingying, Zhou, Zhifen, Liu, Yi, Feng, Ran, Zheng, Jianfei, Songyang, Zhou, Liu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917584/
https://www.ncbi.nlm.nih.gov/pubmed/31921849
http://dx.doi.org/10.3389/fcell.2019.00337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917584/
https://www.ncbi.nlm.nih.gov/pubmed/31921849
http://dx.doi.org/10.3389/fcell.2019.00337

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