Pharmacological Profile of the Sodium Current in Human Stem Cell-Derived Cardiomyocytes Compares to Heterologous Nav1.5+β1 Model

The cardiac Nav1.5 mediated sodium current (I(Na)) generates the upstroke of the action potential in atrial and ventricular myocytes. Drugs that modulate this current can therefore be antiarrhythmic or proarrhythmic, which requires preclinical evaluation of their potential drug-induced inhibition or...

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Detalles Bibliográficos
Autores principales: Van de Sande, Dieter V., Kopljar, Ivan, Teisman, Ard, Gallacher, David J., Snyders, Dirk J., Lu, Hua Rong, Labro, Alain J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917651/
https://www.ncbi.nlm.nih.gov/pubmed/31920633
http://dx.doi.org/10.3389/fphar.2019.01374

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917651/
https://www.ncbi.nlm.nih.gov/pubmed/31920633
http://dx.doi.org/10.3389/fphar.2019.01374

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