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One-Pot Radiosynthesis and Biological Evaluation of a Caspase-3 Selective 5-[(123,125)I]iodo-1,2,3-triazole derived Isatin SPECT Tracer
Induction of apoptosis is often necessary for successful cancer therapy, and the non-invasive monitoring of apoptosis post-therapy could assist in clinical decision making. Isatins are a class of compounds that target activated caspase-3 during apoptosis. Here we report the synthesis of the 5-iodo-1...
Autores principales: | Glaser, Matthias, Rajkumar, Vineeth, Diocou, Seckou, Gendron, Thibault, Yan, Ran, Sin, Pak Kwan Brian, Sander, Kerstin, Carroll, Laurence, Pedley, R. Barbara, Aboagye, Eric O., Witney, Timothy H., Årstad, Erik |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917698/ https://www.ncbi.nlm.nih.gov/pubmed/31848442 http://dx.doi.org/10.1038/s41598-019-55992-0 |
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