Targeting of cell-free DNA by DNase I diminishes endothelial dysfunction and inflammation in a rat model of cardiopulmonary bypass

The use of cardiopulmonary bypass (CPB) results in the activation of leukocytes, release of neutrophil extracellular traps (NETs) and severe inflammation. We hypothesize that targeting of circulating cell-free DNA (cfDNA) by DNases might represent a feasible therapeutic strategy to limit CPB-associa...

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Detalles Bibliográficos
Autores principales: Weber, Carolyn, Jenke, Alexander, Chobanova, Vasilena, Yazdanyar, Mariam, Chekhoeva, Agunda, Eghbalzadeh, Kaveh, Lichtenberg, Artur, Wahlers, Thorsten, Akhyari, Payam, Paunel-Görgülü, Adnana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917735/
https://www.ncbi.nlm.nih.gov/pubmed/31848423
http://dx.doi.org/10.1038/s41598-019-55863-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917735/
https://www.ncbi.nlm.nih.gov/pubmed/31848423
http://dx.doi.org/10.1038/s41598-019-55863-8

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