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Targeting of cell-free DNA by DNase I diminishes endothelial dysfunction and inflammation in a rat model of cardiopulmonary bypass
The use of cardiopulmonary bypass (CPB) results in the activation of leukocytes, release of neutrophil extracellular traps (NETs) and severe inflammation. We hypothesize that targeting of circulating cell-free DNA (cfDNA) by DNases might represent a feasible therapeutic strategy to limit CPB-associa...
Autores principales: | Weber, Carolyn, Jenke, Alexander, Chobanova, Vasilena, Yazdanyar, Mariam, Chekhoeva, Agunda, Eghbalzadeh, Kaveh, Lichtenberg, Artur, Wahlers, Thorsten, Akhyari, Payam, Paunel-Görgülü, Adnana |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917735/ https://www.ncbi.nlm.nih.gov/pubmed/31848423 http://dx.doi.org/10.1038/s41598-019-55863-8 |
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