Antigen-binding affinity and thermostability of chimeric mouse-chicken IgY and mouse-human IgG antibodies with identical variable domains

Constant (C)-region switching of heavy (H) and/or light (L) chains in antibodies (Abs) can affect their affinity and specificity, as demonstrated using mouse, human, and chimeric mouse-human (MH) Abs. However, the consequences of C-region switching between evolutionarily distinct mammalian and avian...

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Detalles Bibliográficos
Autores principales: Choi, Juho, Kim, Minjae, Lee, Joungmin, Seo, Youngsil, Ham, Yeonkyoung, Lee, Jihyun, Lee, Jeonghyun, Kim, Jin-Kyoo, Kwon, Myung-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917740/
https://www.ncbi.nlm.nih.gov/pubmed/31848417
http://dx.doi.org/10.1038/s41598-019-55805-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917740/
https://www.ncbi.nlm.nih.gov/pubmed/31848417
http://dx.doi.org/10.1038/s41598-019-55805-4

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